WikiJournalClub talk:High-priority articles
From Wiki Journal Club
- CONFIRM-HF - Iron for HF with iron deficiency
- 2010 TALC: Tiotropum in addition to inhaled corticosteroids for asthma. 
- 2005 APPROVe: Rofecoxib (Vioxx) in colorectal cancer, increased MIs 
- 2003 CALGB 9741: Dose-dense AC in breast cancer 
- 2002 MIRACLE: Cardiac resynchronization in HF 
- 2000 Daily Sedation Holidays in ICU: Daily Sedation Holidays in Vented Patients in the ICU 
- 2000 VIGOR: Rofecoxib (Vioxx) in RA, notable for selective exclusion of MI data 
- 1998 Autism and the MMR vaccine in children: The infamous (now retracted) Lancet article reportedly linking vaccinations with the MMR vaccine
- 1998 SCCOPE: Duration of corticosteroids in COPD exacerbations 
- 1997 ESSENCE: LMWH vs. UFH in UA 
- 1993 CSG: ACE inhibitors in preventing diabetic nephropathy 
Top WJC Search Terms
- 1994 CIBIS: Bisoprolol in HF 
- 2011 SHARP: Simvastatin and ezetimibe in CKD 
- 2011 ARISTOTLE: Apixaban vs. warfarin in afib 
- 1999 CHARM: Candesartan in HF 
- 1998 LIPID: Pravastatin in CAD 
- 1994 4S: Simvastatin in CHD 
- 2008 ACCOMPLISH: Benazepril + amlodipine or HCTZ for HTN in high-risk patients 
- 2002 Heart Protection Study: Simvastatin + vitamin E, vitamin C, or beta carotene if high risk for CVD 
- 2004 PROVE-IT, TIMI 22: Intensive vs. moderate statin therapy in ACS 
- 2006 CHARISMA: Clopidogrel + ASA vs. ASA alone for atherothrombotic events 
- 2007 MENDS: Sedation with dexmedetomidine vs. lorazepam in mechanical ventilation 
- Recommendations from L. Lanthier
- The only problem that I see is that recent major trial are not all there (those in 2010-2012). Here is a list of studies that changes practice/treatment in the last 2-3 years :
- RAFT (N Engl J Med 2010 ; 363 : 2385-95)
- STICH (N Engl J Med 2011;364:1607-16)
- ARISTOTLE (N Engl J Med 2011;365:981-92).
- ROCKET-AF (N Engl J Med 2011;365:883-91).
- Azithromycin for COPD (N Engl J Med 2011;365:689-98).
- Outpatient treatment of PE (Lancet 2011;378:41-8)
- ATLAS ACS-2 (N Engl J Med 2012 ; 366 : 919)
- Recommendations from T. Sirich
- National Cooperative Dialysis Study (NCDS), Lowrie et al, NEJM 1981.
- A mechanistic analysis of the National Cooperative Dialysis Study (NCDS), Gotch and Sargent, Kidney International 1985
- Effect of dialysis dose and membrane flux in maintenance hemodialysis (HEMO study), Eknoyan et al, NEJM 2002.
- In-center hemodialysis six times per week versus three times per week (FHN study), Chertow et al, NEJM 2010.
- Continuous renal replacement therapy
- Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury (ATN trial), NEJM 2008
- Peritoneal dialysis
- Adequacy of dialysis and nutrition in continuous peritoneal dialysis: association with clinical outcomes. Canada-USA (CANUSA) Peritoneal Dialysis Study Group, JASN 1996.
- Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial (ADEMEX), JASN 2002.
- --mlam 00:08, 24 May 2012 (PDT)
I found this and thought that it might be helpful 
Infamous Lancet autism article
- I'm all for it. --Dave Iberri 16:59, 5 February 2013 (PST)
From the kind folks in the FOAM team (T. Raine and S. Trueger)
- weingart levitan on oxygenation
- lactate clearance vs scvo2 in sepsis (jones, shapiro 2010)
- PECARN on imaging mTBI in kids (Kuppermann 2009)
- R Body on HPI features of AMI 
- overview of crowding 
- seminal paper on boarding as the source of crowding 
- we diagnosis lots more PEs but can't do anything about it except make people bleed 
- odds ratios of individual hpi & pe elements for PE (from PERC dataset) Courtney DM, Kline JA et al 
- single hypotensive episode in ED associated w/ mortality 
- perry CT for SAH within 6h of onset 
- just 2 of the major panscan in trauma articles   (the second one has 2 different conclusions from surgeons vs EM)
- lack of utility of stress tests on <40 yo 
- no difference in typical vs atypical vs no chest pain anginal equivalent 
- low yield of stress tests 
- Failure of electric shock treatment for rattlesnake envenomation 
- "Based on their understanding of an article in an outdoorsman's magazine, the patient and his neighbor had previously established a plan to use electric shock treatment if either was envenomated. The patient was placed supine next to a car, and a spark plug wire was attached to his upper lip by a wire with a small clip at each end. The engine was started and repeatedly rewed to 3,000 rpm for approximately five minutes. The patient lost consciousness with the first electrical charge."
- Non-DHP CCBs in DM nephropathy, will need to choose best trial from this list --Tim Plante (talk) 07:12, 3 August 2013 (PDT)