WikiJournalClub:List of landmark papers/Cardiology

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Hypertension

Stable CAD

PCI/CABG

RAAS inhibition

Acute Coronary Syndrome

Antiplatelets

Anticoagulation

β-blockers

GPIIb/IIIa Inhibitors

PCI/CABG

Lytics

RAAS inhibitors

Statins

ICD/CRT

  • 2003 DINAMIT Prophylactic ICD in post-MI LV dysfunction [50]
  • 2003 IRIS Prophylactic ICD early-post-MI [51]
  • 2009 MADIT-CRT ICD-CRT in LV dysfunction and prolonged QRS [52]

Risk Assessment

  • 2000 TIMI Risk stratification in UA/NSTEMI [53]
  • 2012 ROMICAT-II: CT coronary angiography in acute chest pain [54]

Atrial Fibrillation

Epidemiology

  • ATRIA Risk factors in AF

Management

  • 2001 ACUTE TEE in AF [55] *363*
  • 2002 AFFIRM Rate vs. rhythm control in chronic AF [56] *1993 cites*
  • 2002 RACE Rate vs. rhythm control in chronic AF
  • 2008 AF-CHF Rate vs. rhythm control in AF and HF [57] *421*
  • 2010 RACE II Lenient vs. strict rate control in permanent AF [58]

Antiarrhythmics

  • 2000 CTAF Amiodarone vs. sotalol or propafenone in AF [59]
  • 2005 SAFE-T Amiodarone vs. sotalol in AF
  • 2007 ADONIS Dronedarone for maintenance of SR in AF [60] *341*
  • 2009 ATHENA Dronedarone in AF [61] *479*

Anticoagulation

  • 1989 AFASAK Warfarin vs. aspirin in chronic AF [62] *1030*
  • 1990 BAATAF Warfarin in chronic AF [63] *911 cites*
  • 1991 SPAF I Warfarin vs. aspirin in chronic AF
  • 1992 SPINAF Warfarin in chronic AF [64] *827*
  • 1994 SPAF II Warfarin vs. aspirin in AF [65] *809*
  • 1996 SPAF III Adjusted-dose warfarin vs. low-dose warfarin plus aspirin in AF [66] *858*
  • 2000 HAEST LMWH vs. aspirin in AF [67]
  • 2003 SPORTIF III Ximelagatran vs. warfarin in AF [68] *662*
  • 2006 ACTIVE W Warfarin vs. aspirin plus clopidogrel in AF [69] *1996*
  • 2007 BAFTA Warfarin vs. aspirin for AF in elderly [70] *508*
  • 2009 ACTIVE Plavix and aspirin in AF [71] *427*
  • 2009 RE-LY Dabigatran vs. coumadin in AF [72] *1577*
  • 2011 ROCKET AF Rivaroxaban vs. warfarin in AF [73] *444*
  • 2011 ARISTOTLE Apixaban vs. warfarin in AF [74] *388*
  • 2011 AVERROES Apixaban vs. aspirin in AF [75] *321*


CHF

Hydralazine & nitrates

  • 1986 V-HeFT ISDN/hydralazine in CHF [76]
  • 1991 V-HeFTII Hydralazine & nitrates vs. Ace-inhibitors in CHF [77]
  • 2004 A-HeFT ISDN/hydralazine in blacks with NYHA class III-IV CHF [78]

β-blockers

Ace-inhibitors

ARBs

Aldosterone antagonists

  • 1999 RALES Spironolactone in NYHA III/IV CHF & EF <= 35% [92]
  • 2003 EPHESUS Eplerenone in post-MI patients with LV dysfunction EF≤40% [93]
  • 2011 EMPHASIS-HF Eplerenone in NYHA II CHF with LVEF <30% [94]

Digoxin

  • 1997 DIG Digoxin in CHF with LVEF ≤45%[95]

ICD

Volume management

  • 2007 UNLOAD Ultrafiltration in CHF (JACC 2007;49:675)
  • 2010 DOSE Continuous vs. intermittent lasix
  • 2012 CARRESS-HF Ultrafiltration in decompensated HF [104]

Nesiritide

LVAD

Fish oil

Telemonitoring

Cardiac Risk Assessment

  • 2004 CARP Revascularization before elective vascular surgery [111]
  • 2008 POISE Perioperative metoprolol succinate [112]
  • 2009 DECREASE Preoperative fluvastatin [113]
  • 2009 DECREASE-V Revascularization in high-risk patients before major vascular surgery [114]
  • 2012 VISION: Post-op troponin for predicting mortality [115]

Endocarditis

  • 2012 EASE Early surgery for endocarditis [116]